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Title:  Bioanalytical Chemist, Point of Care Diagnostics

Requisition ID:  48185
Date:  Apr 26, 2022
Location: 

Exton, Pennsylvania, US

Department:  R&D
Description: 

 

 

Working at West means having an opportunity to work by the side of our patients and customers, our global team members and the communities in which we operate – which all help contribute to a Healthier World.

 

At West, we are by the side of patients. The work we do impacts patients’ lives each and every day – our products are a critical part of healthcare delivery and we are proud of the role we play to improve patient health. We work by the side of our team members. We come together as one global team to deliver for our customers and help them address their challenges. We are a diverse, close-knit community of professionals, where everyone has a voice and opportunity to learn and grow through mutual trust and respect. With a 95 year plus history, we have a track record for success, which includes reported sales of $2.14B in 2020. We serve by the side of our community. Giving back is in our DNA—our team members across more than 50 sites globally are involved with hundreds of charities that have special meaning to them through our West Without Borders team member-led giving program.

 

Job Summary:

The Applied Research & Technology Scouting (AR&TS) team within West is responsible for driving the future of the company by identifying and developing innovative products designed to improve patient lives.  This objective will be accomplished through a mix of internal organic research and external inorganic collaboration.  The inorganic effort will span early-stage academic research to more established technologies in the private sector.  The inorganic effort will seed the organic efforts.  The scope encompasses technology fields that are adjacent to and transformational to West’s core products. 

The role will work within the recently established Diagnostic Research & Detection Technology team to identify and evaluate technologies and concepts in a broadly defined Biosensor space.  The team’s output will feed the development of new products and serve new markets.  The timeline for realization of the products is within a 5-year time horizon.  Internal to West this team will collaborate with teams focused on drug delivery and novel therapies.  External to West the team will be interfacing with researchers from academic institutions translating potential value-adding technologies, through feasibility and into reality.  Projects will focus on technology validation and integration.  This will require the planning and performing of experiments, designing test equipment and prototypes, and integrating different principles of optical, mechanical, and electronic engineering.

Amongst the many research avenues of interest to West is the exploration of advanced biometric sensor technologies, and their potential integration into next generation drug delivery devices.  Suitable candidates will be expected to bring a depth of expertise, knowledge of current developments in both research and industry, and will make a significant contribution to the I&T Team and the future of West.  

Essential Duties and Responsibilities:

  • Performs research activities and other tasks in a laboratory environment.
  • Perform biochemistry experiments, including basic tissue culture techniques, isolation of proteins from tissues cells, Western blotting, and immunohistochemistry immunofluorescence.
  • Develop and optimize biochemical and protein-based assays in 384-wells format.
  • Support biosensors for point-of-care rapid tests using electrochemistry, clinical biochemistry, and surface chemistry.
  • Support novel chemistry methods for sensing blood gases, electrolytes, and other analytes.
  • Evaluate new technologies and instruments resulting in proposals for new screening strategies and novel assay formats.
  • Search existing literature; propose, design and test alternative assays for difficult target biomarkers.
  • Collaborate with staff on cutting-edge cell biology and bioassay technologies for the development of disease-relevant assays for screening.
  • Use molecular biological techniques for the generation and improvement of antibodies used in biosensor development.
  • Develop and optimize novel bioanalytical methods based on the future needs.
  • Develop and optimize cell-based and biochemical assays to support biosensor development.
  • Work with staff on assay design and modification with the input from published scientific literature.
  • Records observations and measurements and reports results at weekly laboratory meetings.
  • Analyze experiment results and present findings in project meetings.
  • Documents and analyzes data from experiments.
  • Contribute to complex research projects across several technologies and a variety of project formats, from short-term student internships, through to feasibility projects and long-term collaborations.
  • Execute experimental plans and project proposals to evaluate different technologies and test hypotheses.

Basic Qualifications:

  • Education: Bachelor’s (3 years) or Master’s (1-2 years) of PhD (0-1 year) in a scientific or engineering discipline.
  • Experience: 3-5 years’ experience in scientific or engineering discipline.
  • Background working in medical device or similarly regulated industry.
  • Demonstrated ability to support complex research projects either through relevant industry projects or via strong collaborative research.
  • Willingness to learn and to independently explore new fields of research, understand nascent technologies.
  • Excellent written and verbal communication and ability to articulately disseminate scientific research to a variety of different audiences, from biomedical, mechanical, electronic engineering or equivalent expert through to non-technical.

 

Preferred Knowledge, Skills and Abilities:

  • Fundamental understanding of protein biochemistry and bioconjugation chemistry.
  • Experience with bioanalytical assay development and validation, and common bioanalytical techniques such as spectroscopy, gel electrophoresis, etc.
  • Working understanding of manual methods and immunoassay technologies such as ELISA.
  • Skilled at method development and validation.
  • Hands-on experience with different sample preparation procedures such as protein precipitation, liquid-liquid extraction, solid-phase extraction and immunocapture approaches.
  • Expertise in designing and developing biochemical assays used to detect biomarkers in biological samples.
  • Expertise in micro fluidic and lateral flow assay development.
  • Experience with PCR, and cell-based bioassay is a plus.
  • Hands-on experience with LC-MS/MS and/or ligand binding immunoassays is required.
  • Experience performing immunoassays or other detail-oriented procedures is desirable.
  • Able to be aware of all relevant SOPs as per Company policy as they are related to the position covered by this Job Description

 

Travel Requirements:

  • Must be able to travel domestically or internationally up to 15% of the time

 

Physical & Mental Requirements:

  • Must maintain the ability to work well with others in a variety of situations.
  • Must be able to multi-task, work under time constraints, problem solve, and prioritize.

 

 

 

 

 

 

West is an equal opportunity employer and we value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sex, gender identity, sexual orientation, age, marital status, veteran status, or disability status.  If you have a special need that requires accommodation in order to apply to West, please send an email to Apply.Accommodation@westpharma.com.  Where permitted by law, an offer of employment with West Pharmaceutical Services, or any of its subsidiary or affiliate companies, is contingent upon the satisfactory completion of background screening and/or a pre-employment drug screening.

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